In vivo analysis of intestinal permeability following hemorrhagic shock

Figure 1 Increased bowel permeability to casein peptides after hemorrhagic shock. Small bowel permeability as measured by systemic concentrations of proteolytically-generated peptides from fluorescently labelled casein injected into the small bowel. Note the early increase in bowel permeability at 20 min, followed by a second, sustained increase in bowel permeability at reperfusion. Values normalized to background fluorescent levels in the systemic circulation at time T = 0 and plotted as log₁₀ concentrations. Results reported as Mean ± SD. ^aP < 0.05, ^bP < 0.01, ^dP < 0.001 using Repeated Measures ANOVA for hemorrhagic shock (n = 6) vs sham-shock control (n = 6) groups at each time point.