Inhaled hypertonic saline for cystic fibrosis: Reviewing the potential evidence for modulation of neutrophil signalling and function

Figure 1 Classification of cystic fibrosis transmembrane conductance regulator mutations. CFTR mutations are classified into six groups according to their effect on CFTR function. Class I mutations affect biosynthesis, while class II mutations affect protein processing. Milder mutations such as class II to Class V impair CFTR channel function. CFTR: Cystic fibrosis transmembrane conductance regulator.