Landiolol, an ultra-short-acting β1-blocker, is useful for managing supraventricular tachyarrhythmias in sepsis

Table 2 Hemodynamics

	Landiolol	Control
Heart rate, bpm	145 ± 14a	136 ± 21
Systolic arterial pressure, mmHg	113 ± 34a	137 ± 39
Diastolic arterial pressure, mmHg	60 ± 17	66 ± 13
Mean arterial pressure, mmHg	78 ± 21	86 ± 28
Diastolic pulmonary arterial pressure, mmHg	19 ± 6	20 ± 7
Cardiac output, L/min	3.9 ± 1.7	5.8 ± 1.5
Cardiac index, L/min per square meter	2.5 ± 1.1a	4.0 ± 1.3
SVRI, dyne∙s/m5 per square meter	2068 ± 795	1615 ± 399
Arrhythmia
Paroxysmal atrial fibrillation/flutter	34 (87%)	13 (60%)
Paroxysmal atrial tachycardia	4 (10%)	8 (36%)
Paroxysmal supraventricular tachycardia	1 (3%)	1 (5%)
Concomitant drugs to control arrhythmia
Calcium-channel blocker	3 (8%)	5 (22%)
Other β blockers	0 (0%)	3 (14%)
Disopyramid phosphate	0 (0%)	1 (5%)
Amiodarone	0 (0%)	1 (5%)

^aP < 0.05 vs control. SVRI: Systemic vascular resistance index.