Myeloproliferative and thrombotic burden and treatment outcome of thrombocythemia and polycythemia patients

Table 5 Top 20 clinical manifestations in patients with who defined myeloproliferative neoplasm essential thrombocythemia, polycythemia vera and myelofibrosis based on the Dutch myeloproliferative neoplasm Questionaire 2009-2010[23]

Symptom	Top 20 MPN complaints	All MPN	MPN	ET	PV	MF
		n = 497	%	%	%	%
1	Fatigue, listless	399	81	80	81	85
2	Microvascular acra37	278	57	61	56	46
3	Cognitive disturbances37	262	53	52	56	45
4	Visual disturbances37	249	51	50	52	46
5	Night sweats	236	48	44	50	52
6	Itching	220	45	30	58	36
7	Dizziness	218	44	44	46	39
8	Bruises, bleedings	211	43	40	45	43
9	Splenomegaly constitutional symptoms	198	40	22	43	78
10	Tinnitus	188	38	38	39	37
11	Migraine headache without visual symptoms	184	37	46	35	22
12	Bone pain	172	35	33	36	34
13	Heart arrythmias	154	31	34	31	24
14	Dysarthria, dyslexia	151	31	31	31	30
15	Hypersensitive to sounds and noices	149	30	29	32	28
16	Paleness	145	29	30	26	40
17	Claudicatio intermittens	140	28	28	30	24
18	Hypersensitive to lights	136	28	25	32	16
19	Visual disturbances without headache	18	33	54	3	90
20	Headache without visual symptoms	24	43	43	4	90

Microvascular acra: Tingling, prickeling sensations, redness,swelling and/or bluish discolouration of footsoles, handpalms, toes and/or fingers³⁷. Cognitive disturbances of concentration and memory and sudden attacks of unconscienceness. Visual disturbances of scintillating scotomas, light flashes, blurred vision, transient monocular blindness, rapid spreading of visual figure disturbances³⁷. Attacks of migraine-like headaches followed by nausea or vomiting or loss of consciencenous or transient paresis of one extermity³⁷. MPN: Myeloproliferative neoplasm; ET: Essential thrombocythemia; PV: Polycythemia vera; MF: Myelofibrosis.