Thoracic epidural anesthesia: Effects on splanchnic circulation and implications in Anesthesia and Intensive care

Table 7 Ongoing clinical trials

Title	Start year	Scenario	No. subjects	Current primary outcome measures	Current secondary outcome measures	Findings
Effect of Epidural Anesthesia on Pancreatic Perfusion and Clinical Outcome in Patients With Severe Acute Pancreatitis	July 2005	Acute pancreatitis with Ranson Criteria over 2, and/or CRP over 100, and or pancreatic necrosis on CT scan	35 (epidural anesthesia with carbostesin and fentanyl vs PCA with fentanyl)	Number of patients with adverse events related to epidural anesthesia, pancreatic perfusion measured by computerized tomography	Clinical outcome, Lenght of stay, admission to intensive care unit, need for surgery	n/d
Epidural Analgesia for Pancreatitis (Epipan Study)	April 2014	Patients admitted to the ICU for acute pancreatitis	148 (PCEA with Ropivacaine and sufentanyl vs conventional analgesia - acetaminophen, nefopam, tramadol, opidoids)	Ventilator-free days	Duration of invasive and/or non invasive mechanical ventilation, incidence of various complications, biological inflammatory response, cost analysis, incidence of intolerance to enteral feeding, effectiveness of pain management, duration of EA	n/d
Study of Effectiveness of Thoracic Epidural Analgesia for the Prevention of Acute Pancreatitis After ERCP Procedures	January 2008	Patients undergoing therapeutic ERCP for the first time without clinical signs of acute pancreatitis	491 (standard premedication + TEA vs standard premedication)	prevention of post-ERCP pancreatitis	Not provided	n/d
The Effects of Local Infiltration Versus Epidural Following Liver Resection 2 (LIVER 2)	December 2012	Patients undergoing open hepatic resection for benign or malignant conditions	100 (EA vs wound catheter)	Length of stay	Pain Scores, Molecular response to surgery, Central Venous Pressure, estimated Blood Loss, Operative field asessment, Pringle time, Quality of Life (EQ-5D), Morphine consumption, IV Fluid volume, Complications, Post-operative blood tests	n/d