Invasive candidiasis in critical care setting, updated recommendations from “Invasive Fungal Infections-Clinical Forum”, Iran

Table 2 Recommended therapy with proper dosing in invasive candidiasis based on the current practice guidelines and consensus statements[12,14-16]

Recommended treatment	Candidemia(non-neutropenic patients, moderate to severe illness)	Candidemia(neutropenic patients)	Candidaglabrata	Candida parapsilosis	Solid organ transplant recipients (prophylaxis)	ICU prophylaxis(high risk patients only)
Caspofungin	70 mg iv loading dose, then 50 mg/d per iv	70 mg iv loading dose, then 50 mg/d per iv	70 mg iv loading dose, then 50 mg/d per iv
Micafungin	100 mg/d per iv	100 mg/d per iv	100 mg/d per iv
Anidulafungin	200 mg/iv loading dose; then 100 mg/d per iv	200 mg/iv loading dose; then 100 mg/d per iv	200 mg/iv loading dose; then 100 mg/d per iv
Fluconazole				800 mg iv loading, then 400 mg/d per iv or PO	200-400 mg/d iv or PO for 7-14 d	400 mg/d per iv or PO
(Alternative regimen) Fluconazole	800 mg iv loading, then 400 mg/d per iv or PO	800 mg iv loading, then 400 mg/d per iv or PO
(Alternative regimen) Voriconazole if mold coverage is desired		6 mg/kg per iv q12h for 2 doses; then 4 mg/kg iv q12h or 200 mg PO q12h
(Alternative regimen) Fluconazole or Voriconazole			With susceptibility testing
(Alternative regimen) Echinocandins				If already responding to therapy
(Alternative regimen) Liposomal Amphotericin B					1-2 mg/kg iv/d for 7-14 d

ICU: Intensive care unit; PO: Per Os (Oral administration); iv: Intravenous.