Systematic Reviews
Copyright ©The Author(s) 2025.
World J Crit Care Med. Jun 9, 2025; 14(2): 99975
Published online Jun 9, 2025. doi: 10.5492/wjccm.v14.i2.99975
Table 9 Sedation and anesthesia protocols for children with autism spectrum disorder in the emergency setting1
Protocol component
Guidelines
Pre-procedure assessment
Medical historyObtain a detailed medical history, including any previous reactions to sedation or anesthesia
Review comorbid conditions, current medications, and allergies
Behavioral assessmentAssess baseline behaviors and any known triggers for anxiety or behavioral issues
Consult with caregivers for effective calming strategies and past experiences with sedation
Preparation for sedation/anesthesia
CommunicationExplain the procedure to the child using simple language and visual aids
Involve caregivers to help explain and reassure the child
Familiar itemsAllow the child to have familiar comfort items during the preparation phase
Pre-medicationConsider using anxiolytics or mild sedatives as premedication to reduce anxiety and agitation
Sedation/anesthesia plan
Tailored dosageAdjust dosages based on the child’s weight, age, and medical history
Use the lowest effective dose to achieve the desired level of sedation or anesthesia
Medication choiceSelect sedatives and anesthetics with a favorable safety profile and minimal side effects
Avoid medications known to exacerbate behavioral issues or cause adverse reactions in children with ASD
Multidisciplinary ConsultationInvolve a pediatric anesthesiologist and other specialists as needed to develop a comprehensive plan
During sedation/anesthesia
MonitoringContinuously monitor vital signs, including heart rate, respiratory rate, blood pressure, and oxygen saturation
Observe for any signs of distress, adverse reactions, or changes in behavior
Behavioral observationMonitor behavioral responses to sedation, noting any unusual or unexpected reactions
Post-procedure care
Recovery monitoringMonitor the child closely during the recovery phase for any delayed reactions or complications
Ensure a calm and quiet environment to facilitate smooth recovery
Pain managementProvide appropriate pain relief post-procedure, considering the child’s pain threshold and sensitivities
Use non-pharmacological methods in conjunction with medication for effective pain management
Caregiver involvementAllow caregivers to be present during recovery to provide comfort and reassurance
Educate caregivers on what to expect during the recovery period and signs of potential complications
Documentation and follow-up
Detailed documentationDocument all sedation/anesthesia process aspects, including medications used, dosages, and responses
Record any adverse reactions or complications and the interventions used to address them
Follow-up careSchedule follow-up appointments to monitor the child’s recovery and address any ongoing concerns
Provide caregivers with contact information for post-procedure questions or emergencies