Cannabis use disorder and severe sepsis outcomes in cancer patients: Insights from a national inpatient sample

Table 1 Baseline demographics, hospital-specific admitting characteristics and co-morbidities among cancer patients admitted for severe sepsis with vs without cannabis use disorder

Baseline characteristics of cancer patients hospitalized with severe sepsis (n = 743520)	CUD(-) (n = 738575)	CUD(+) (n = 4945)	P value
Demographics
Age at admission, years (median with 25th-75th percentile values)	69 (61-77)	58 (49-64)	< 0.001
Sex	-	-	< 0.001
Males	57.2	67.9	-
Females	42.8	32.1	-
Race	-	-	< 0.001
White	70.8	64.8	-
Black	14.4	23.7	-
Hispanic	10	9.5	-
Asian or Pacific Islander	4.3	1.1	-
Native American	0.6	0.9	-
Median household income1	-	-	< 0.001
0th-25th	27.2	36.7	-
26th-50th	25	26.9	-
51th-75th	24.6	21.5	-
76th-100th	23.2	14.9	-
Payer type	-	-	< 0.001
Medicare	66.1	38.2	-
Medicaid	10.7	35.2	-
Private	21.4	22.4	-
Self-pay	1.8	4.1	-
No charge	0.1	0.1	-
Hospital-specific admitting characteristics	-	-	-
Hospital location and teaching status2	-	-	< 0.001
Rural	6	5.6	-
Urban non-teaching	19.5	15.8	-
Urban teaching	74.5	78.7	-
Hospital region	-	-	< 0.001
Northeast	17.9	10.8	-
Midwest	21	20.3	-
South	36.8	34.8	-
West	24.2	34.1	-
Comorbidities
Acquired immunodeficiency syndrome	0.9	4.7	< 0.001
Diabetes without chronic complications	11	7.3	< 0.001
Diabetes with chronic complications	18.8	12.9	< 0.001
Hypertension, complicated	29.6	19.3	< 0.001
Hypertension, uncomplicated	29.4	31	0.012
Hyperlipidemia	31.1	20.3	< 0.001
Chronic pulmonary disease	26.1	34.8	< 0.001
Obesity	12	10.4	0.001
Peripheral vascular disease	7.6	8.2	0.11
Hypothyroidism	13.2	7.3	< 0.001
Valvular disease	1.1	0.3	< 0.001
Tobacco use	25.2	28.8	< 0.001
Alcohol abuse	2.9	13.1	< 0.001
Cocaine use	0.2	6.9	< 0.001
Depression	9.8	16.2	< 0.001
Prior myocardial infarction	4.5	4.7	0.521
Prior transient ischemic attack or stroke	4.4	3.7	0.022
Prior cancer	15.3	14.3	0.038
Prior chemotherapy	9.6	12.2	< 0.001
Prior radiotherapy	6.6	8.9	< 0.001
Autoimmune conditions	3	2.2	0.003

¹Quartile classification of estimated median household income based on patients' ZIP code, https://hcup-us.ahrq.gov/db/vars/zipinc_qrtl/nrdnote.jsp

²A teaching hospital is one that has at least one Accreditation Council for Graduate Medical Education-approved residency program. Urban/rural classification is designated by Core Based Statistical Area, https://hcup-us.ahrq.gov/db/vars/hosp_bedsize/nrdnote.jsp

Values are in percentages unless specified. Accompanying P value for significance. CUD: Cannabis use disorder.