Predicting the risk of mortality in children with dengue-induced hepatitis admitted to the paediatric intensive care unit

Table 4 Multivariable logistic models for predicting 28-day in-hospital mortality among dengue shock syndrome children with clinical predictors and biomarkers

Prognostic factors	Model 1		Model 2		Model 3
	OR (95%CI), Pa		OR (95%CI),Pb		OR (95%CI), Pc
Pain and unresponsive levels on the Alert, Verbal, Pain, Unresponsive scale	13.86 (3.71-51.8)	< 0.001	14.36 (4.12-50.1)	< 0.001	13.96 (3.73-52.2)	< 0.001
High vasoactive inotropic score (> 30)	18.1 (4.99-65.4)	< 0.001	17.4 (5.06-60.2)	< 0.001	18.0 (4.98-65.3)	< 0.001
Highest level of blood lactate (mmol/L)	1.5 (1.27-1.78)	< 0.001	1.62 (1.37-1.91)	< 0.001	1.5 (1.27-1.78)	< 0.001
International normalized ratio levels, ≥ 2.11	11.3 (2.62-48.3)	0.001	_	_	9.1 (1.72-47.9)	< 0.01
Peak serum bilirubin level, ≥ 1.7 mg/dL	_	_	4.72 (1.12-19.8)	0.03	1.5 (0.29-7.81)	0.62

P^a, P^b, and P^c withdrawn from multivariable logistic analyses with multiple imputation data. Model 1: Clinical predictors and international normalized ratio (INR); Model 2: Clinical predictors and total serum bilirubin; Model 3: Clinical predictors, INR, and total serum bilirubin. OR: Odds ratio.