Predicting the risk of mortality in children with dengue-induced hepatitis admitted to the paediatric intensive care unit

Table 3 Clinical predictors of in-hospital mortality in pediatric intensive care unit-admitted children with severe dengue-associated hepatitis from univariable and multivariable logistic analyses

Factors	Non-survivors (n = 42)	Survivors (n = 417)	Unadjusted OR (95%CI), Pa	Adjusted OR (95%CI), Pb
Age (years)	7 (4.2-10)	7.8 (4.4-10.2)	0.98 (0.9-1.06), P = 0.55	-
Gender
Female	16 (38)	177 (42)	1.2 (0.62-2.3), P = 0.58	-
Male	26 (62)	240 (58)
Grading of DSS
Compensated DSS	29 (69)	373 (89)	3.8 (1.84-7.85), P < 0.001	-
Decompensated DSS	13 (31)	44 (11)
Severe bleeding
No	11 (26)	372 (89)	23.1 (10.9-49.1), P < 0.001	-
Yes	31 (74)	45 (11)
Levels of consciousness (on the Alert, Verbal, Pain, Unresponsive scale)
Alert and verbal response	15 (36)	387 (93)	23.2 (11.1-48.2), P < 0.001	4.43 (1.12-17.5), P = 0.03
Pain and unresponse	27 (64)	30 (7)
High vasoactive inotropic score (> 30)
No	7 (17)	407 (98)	204 (73-568), P < 0.001	39.2 (9.2-167), P < 0.001
Yes	35 (83)	10 (2)
Peak hematocrit (%)	46 (40-51)	47 (44-51)	0.95 (0.9-0.99), P = 0.024	-
Low platelet counts, (< 20 x 109/L)
No	25 (60)	319 (76)	2.21 (1.15-4.27), P = 0.018	-
Yes	17 (40)	98 (24)
Severe transaminitis
No	9 (21)	260 (62)	6.07 (2.83-13.0), P < 0.001	-
Yes	33 (79)	157 (38)
Serum sodium, (mmol/L)	128 (124-133)	128 (125-131)	1.0 (0.95-1.07), P = 0.74	-
Highest level of blood lactate (mmol/L)	10.3 (7.2-13.4)	2.4 (1.8-4.2)	1.67 (1.47-1.89), P < 0.001	1.61 (1.34-1.94), P < 0.001
Serum creatinine (µmol/L)	73 (58-123)	53 (44-61)	1.03 (1.02-1.04), P < 0.001	-

Summary statistics are median (interquartile) for continuous data and frequency (%) for categorical data. P^a and P^b withdrawn from complete-case analysis univariable and multivariable logistic analyses, respectively. DSS: Dengue shock syndrome; OR: Odds ratio.