Predicting the risk of mortality in children with dengue-induced hepatitis admitted to the paediatric intensive care unit

Table 2 Area under the receiver operating characteristic curve for biomarkers and cut-offs for in-hospital mortality of children experiencing severe dengue-associated hepatitis

Parameters	Area under the curve of mortality (95%CI)	P value	Optimal cutoff points of the parameters	Sensitivity	Specificity		Accuracy	Youden index
INR peak during first 24 hours of PICU admission	0.907 (0.858-0.956)	< 0.001	INR peak ≥ 2.11 during first 24 hours of admission	0.902	0.855		0.859	0.757
Peak of total serum bilirubin during 72 hours of PICU admission (mg/dL)	0.790 (0.704-0.875)	< 0.001	Peak of total serum bilirubin during the first 72 hours of PICU admission ≥ 1.7 (mg/dL)	0.941	0.565	0.672		0.506

INR: International normalized ratio peak; PICU: Pediatric intensive care unit.