Early clinical outcomes of two regimens of prophylactic antibiotics in cardiac surgical patients with delayed sternal closure

Table 4 Clinical outcomes

Variable	All patients	Narrow-spectrum antibiotics, n = 12	Broad-spectrum antibiotics, n = 41	P value
New nosocomial infection	20/50 (40.0)	5	15	0.736
Time to sepsis/septic shock postoperatively in d	4.8 ± 2.6 (N = 50)	3.0 (ΔIQR 4.0) (n = 11)	3.5 (ΔIQR 2.0) (n = 39)	0.586
POAF	24/52 (46.2)	5	19	0.722
New ECG changes	39/51 (76.5)	9	30	1.00
Heart block	7/52 (13.5)	2	5	0.656
LV dysfunction	7/52 (13.5)	0	7	0.181
Postoperative MI	2/52 (3.8)	0	2	1.00
New postoperative stroke				0.576
Transient	3/50 (6.0)	0	3
Permanent	5/50 (10.0)	1	4
Duration of ventilation in h	70.0 (39.0-190)	50.0 (ΔIQR 113)	60.0 (ΔIQR 170)	0.047
LOS-ICU in d	8.0 (3.25-15.5) (N = 52)	5.0 (ΔIQR 5.0) (n = 12)	7.5 (ΔIQR 10.0) (n = 40)	0.008
LOS-hospital in d	27.0 (10.5-47.0) (N = 44)	19.0 (ΔIQR 21.0) (n = 11)	27.0 (ΔIQR 30.0) (n = 33)	0.031
Mortality	18/52 (34.6)	4	14	1.00
Readmission to ICU	5/51 (9.8)	1	4	1.00

Data are total N/subset n (%), median (IQR) or mean ± standard deviation. ECG: Electrocardiographic; ICU: Intensive care unit; IQR: Interquartile range; LOS: Length of stay; LV: Left ventricular; MI: Myocardial infarction; POAF: Postoperative atrial fibrillation.