Early clinical outcomes of two regimens of prophylactic antibiotics in cardiac surgical patients with delayed sternal closure

Table 3 Peri-procedural findings

Variable	All patients	Narrow-spectrum antibiotics, n = 12	Broad-spectrum antibiotics, n = 41	P value
Procedure data				0.398
CABG	31/53 (58.5)	7	24
Valve replacement	11/53 (20.8)	4	7
Combined CABG/valve surgery	6/53 (11.3)	0	6
Aortic dissection	5/53 (9.4)	1	4
Epicardial wires	16/52 (30.8)	4	12	1.00
CPB in min	165 ± 75.3 (N = 50)	127.3 ± 67.9 (n = 10)	174.4 ± 74.9 (n = 40)	0.037
ACC in min	85.0 ± 45.7 (N = 41)	83.2 ± 50.5 (n = 9)	85.4 ± 45.1 (n = 32)	0.451
Open chest duration in d	3.0 (2.0-5.0)	2.0 (ΔIQR 2.0)	3.0 (ΔIQR 2.0)	0.146
Intraoperative transfusion	41/52 (78.8)	10	31	1.00
Postoperative transfusion	49/51 (96.1)	12	37	1.00
Blood loss in mL
At 6 h	700 (375-1350) (N = 45)	900 (ΔIQR 1050) (n = 11)	1050 (ΔIQR 1250) (n = 34)	0.864
At 12 h	1225 (500-2050) (N = 44)	1750 (ΔIQR 1000) (n = 11)	1575 (ΔIQR 2088) (n = 33)	0.881
At 24 h	1700 (775-2800) (N = 45)	1900 (ΔIQR 2500) (n = 11)	2175 (ΔIQR 3213) (n = 34)	0.8443
Total loss	2400 (1362-4700) (N = 44)	2050 (ΔIQR 4375) (n = 11)	3325 (ΔIQR 4300) (n = 33)	0.492
Support
Inotropes/vasopressors use
Agent(s) use	46/47 (97.9)	11	35	1.00
Number of agent(s) used				0.385
0	2/49 (4.1)	0	2
1	3/49 (6.1)	2	1
2	16/49 (32.7)	4	12
3	20/49 (40.8)	5	15
4	8/49 (16.3)	1	7
Number of agents used	2.6 ± 0.9 (N = 49)	2.4 ± 0.9 (n = 12)	2.6 ± 1.0 (n = 37)	0.24
IABP use	27/53 (50.9)	6	21	0.941
Defibrillation	13/53 (24.5)	3	10	1.00

Data are total N/subset n (%), median (IQR) or mean ± standard deviation. ACC: Aortic cross clamp; CABG: Coronary artery bypass grafting; CPB: Cardiopulmonary bypass; IABP: Intra-aortic balloon pump; IQR: Interquartile range.