Serotonin syndrome controversies: A need for consensus

Table 3 An overview of the clinical characteristics of serotonin syndrome in comparison to the Hunter and Sternbach criteria[5,16,24,32]

	Cognitive impairment	Neuromuscular abnormalities	Autonomic abnormalities	Miscellaneous /complications
Sternbach criteria	Agitation	Clonus, hyperreflexia, tremor	Diaphoresis, fever
Hunter criteria	Mental status changes. Agitation	Hyperreflexia, rigidity, tremor, incoordination, shivering	Diaphoresis, fever, diarrhoea
Other clinical features	Insomnia, anxiety, confusion, drowsiness, lethargy, seizures, coma. Psychosis, apathy, mania	Gait problems, dysarthria, myoclonus, babinski, trismus, paresthesias,body pain, headache, fatigue	Tachycardia, hypertension, hypotension, unstable blood pressure, palpitation dizziness, arrhythmia, mydriasis, nausea, vomiting, abdominal pain, hyperactive bowel, sexual dysfunctions, bladder dysfunctions	Rhabdomyolysis PRES, DIC, acute renal failure, Takotsubo cardiomyopath, Cardiogenic shock pulmonary oedema, ARDS, multi-organ failure

PRES: Posterior reversible encephalopathy syndrome; DIC: Disseminated intravascular coagulation; ARDS: Acute respiratory distress syndrome.