Effects of combined aerobic, resistance and inspiratory training in patients with pulmonary hypertension: A systematic review

doi:10.5492/wjccm.v13.i2.92585

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World Journal of Critical Care Medicine

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2220-3141

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Crit Care Med. Jun 9, 2024; 13(2): 92585
Published online Jun 9, 2024. doi: 10.5492/wjccm.v13.i2.92585

Table 1 Main baseline characteristics of patients included in the systematic review

Ref.	Sample size (n)	Sex (Male/Femail)	Mean age (yr)	Type of PH, n (%)	Mean PAP (mmHg)	Mean PVR (dyn × s /cm⁵)	Cardiac index (L/min/m²)	Peak VO₂ (mL/min/kg)	6MWT (m)
Mereles et al[20]	I: 15	5/10	47 ± 12	PAH: 13 (86.6); CT: 2 (13.3)	49.5 ± 17.6	968.7 ± 444.1	2.3 ± 0.5	13.2 ± 3.1	411 ± 86
Mereles et al[20]	C: 15	5/10	53 ± 14	PAH: 11 (73.3); CT: 4 (26.7)	49.6 ± 12.3	901.8 ± 358.0	2.1 ± 0.5	11.9 ± 3.1	439 ± 82
Ley et al[21]	I: 10	2/8	47 ± 8	PAH: 7 (70); CT: 1 (10); Other¹: 2 (20)	48 ± 19	731 ± 256	2.78 ± 0.57	NA	449 ± 80
Ley et al[21]	C: 10	4/6	54 ± 14	PAH: 5 (50); CT: 3 (30); Other¹: 2 (20)	50 ± 15	909 ± 374	2.2 ± 0.51	NA	423 ± 101
Ehlken et al[22]	I: 46	20/26	55 + 15	PAH: 35 (76.1); CT: 11 (23.9)	41.0 + 11.7	540 + 267	2.68 + 0.73	13.3 ± 3.6	453 ± 91
Ehlken et al[22]	C: 41	20/21	57 + 15	PAH: 26 (63.4); CT: 15 (36.5)	37.6 + 11.8	512 + 338	2.69 + 0.89	12.7 ± 4.0	413 ± 95
González-Saiz et al[23]	I: 20	8/12	46 ± 11	PAH: 7 (35); CT: 2 (10); Other²: 11 (55)	47 ± 15	11 ± 6 (WU)	Cardiac output: 4414 ± 91 (ml/min)	15.7 ± 3.3	500 ± 70
González-Saiz et al[23]	C: 20	8/12	45 ± 12	PAH: 11 (55); CT: 2 (10); Other²: 7 (35)	47 ± 14	9 ± 5 (WU)	Cardiac output: 4827 ± 135 (ml/min)	19.8 ± 6.5	546 ± 99
Grünig et al[24]	I: 58	18/40	52.3 ± 12.4	PAH: 39 (67.2); CT: 7 (12.1); Other³: 12 (20.7)	46.5 ± 15.5	8.6 ± 5.5 (WU)	2.7 ± 0.7	14.2 ± 5.2	447.2 ± 117.7
Grünig et al[24]	C: 58	13/45	55.0 ± 12.7	PAH: 34 (58.6); CT: 11 (19.0); Other³: 13 (22.4)	46.7 ± 14.9	7.7 ± 4.5 (WU)	2.8 ± 0.7	15.3 ± 4.3	447.4 ± 120.0

¹PAH associated with connective tissue disease and portal hypertension.

²PAH associated with toxic oil syndrome, connective tissue disorders, HIV and congenital cardiopathy.

³PAH associated with connective tissue disorders and congenital cardiopathy.

I: Intervention group; C: Control group; VO₂: Oxygen consumption; 6MWT: 6-min walking test; PAP: Pulmonary artery pressure; PVC: Pulmonary vascular resistance; PH: Pulmonary hypertension; PAH: Pulmonary arterial hypertension; CT: Chronic thromboembolic; WU: Woods units; NA: Not applicable.

Citation: Kourek C, Zachariou A, Karatzanos E, Antonopoulos M, Soulele T, Karabinis A, Nanas S, Dimopoulos S. Effects of combined aerobic, resistance and inspiratory training in patients with pulmonary hypertension: A systematic review. World J Crit Care Med 2024; 13(2): 92585
URL: https://www.wjgnet.com/2220-3141/full/v13/i2/92585.htm
DOI: https://dx.doi.org/10.5492/wjccm.v13.i2.92585