Diagnosis and management of severe pulmonary and extrapulmonary tuberculosis in critically ill patients: A mini review for clinicians

Table 4 Dose adjustment in antituberculosis therapies in patients with renal dysfunction

Antimycobacterial agent	Normal daily dose in adults	CrCl 30-60	CrCl 10-29	CrCl < 10	Haemodialysis	Peritoneal dialysis
Isoniazid	5 mg/kg (typically 300 mg)	No dose adjustment	No dose adjustment	No dose adjustment	No dose adjustment	No dose adjustment
Rifampicin	10 mg/kg (typically 600 mg)	No dose adjustment	No dose adjustment	No dose adjustment	No dose adjustment	No dose adjustment
Ethambutol	15 mg/kg	15 mg/kg/d	15 mg/kg q48h	15 mg/kg q48h	15 mg/kg three times weekly post-HD	15 mg/kg q48h
Pyrazinamide	15-30mg/kg	No dose adjustment	15-30 mg/kg q48h	15-30 mg/kg three times weekly	15-30 mg/kg three times weekly post-HD	No dose adjustment

HD: Haemodialysis.