Future of neurocritical care: Integrating neurophysics, multimodal monitoring, and machine learning

doi:10.5492/wjccm.v13.i2.91397

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World Journal of Critical Care Medicine

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2220-3141

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World J Crit Care Med. Jun 9, 2024; 13(2): 91397
Published online Jun 9, 2024. doi: 10.5492/wjccm.v13.i2.91397

Table 1 Various proposed cerebral microdialysis substrates

Function	Substrates
ATP usage	Adenosine, hypoxanthine, inosine, K+
Membrane dysfunction	Glycerol
Reactive oxygen species	Xanthine, uric acid, glutathione, cysteine
Nitric oxide formation	Nitrite, nitrate, citrulline, arginine
Brain swelling	Potassium, taurine
Inflammation	IL-1, IL-6, GFAP, TNF
Blood-brain barrier	Alanine, leucine, and valine
Neurotransmitters and amino acids	Serine, 5-HIAA, GABA, Glycine

5-HIAA: 5-hydroxyindoleacetic acid; GABA: Gamma-aminobutyric acid; GFAP: Glial fibrillary acidic protein; IL-1: Interleukin 1; IL-6: Interleukin 6; TNF: Tumor necrosis factor.

Citation: Srichawla BS. Future of neurocritical care: Integrating neurophysics, multimodal monitoring, and machine learning. World J Crit Care Med 2024; 13(2): 91397
URL: https://www.wjgnet.com/2220-3141/full/v13/i2/91397.htm
DOI: https://dx.doi.org/10.5492/wjccm.v13.i2.91397