Inhaled volatile anesthetics in the intensive care unit

doi:10.5492/wjccm.v13.i1.90746

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Mar 9, 2024 (publication date) through Nov 29, 2024

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World Journal of Critical Care Medicine

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2220-3141

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Crit Care Med. Mar 9, 2024; 13(1): 90746
Published online Mar 9, 2024. doi: 10.5492/wjccm.v13.i1.90746

Table 1 Pharmacology and overview of halogenated volatile anesthetics[8,78-81]

	MAC (%)	Blood:Gas at 37^oC	Boiling point (^oC)	Odor	Metabolism (%)	Cardiovascular effects	Central nervous system effects
Halothane	0.75	2.4	122	Organic solvent	15-20	Decrease CO, decrease HR	Decrease CPP, increase CBF
Isoflurane	1.15	1.4	48	Ethereal/pungent	0.2	Decrease CO, increase HR, decrease SVR	Decrease CPP, increase CBF
Desflurane	6.0	0.4	23	Ethereal/pungent	0.02	Increase HR, decrease SVR	Decrease CPP, increase CBF
Sevoflurane	2.0	0.68	59	Organic solvent	5	Decrease SVR	Decrease CPP, increase CBF. Can induce epileptiform EEG

CBF: Cerebral blood flow; CO: Cardiac output; CPP: Cerebral perfusion pressure; EEG: Electroencephalogram; HR: Heart rate; MAC: Minimum alveolar concentration; SVR: Systemic vascular resistance.

Citation: Wieruszewski ED, ElSaban M, Wieruszewski PM, Smischney NJ. Inhaled volatile anesthetics in the intensive care unit. World J Crit Care Med 2024; 13(1): 90746
URL: https://www.wjgnet.com/2220-3141/full/v13/i1/90746.htm
DOI: https://dx.doi.org/10.5492/wjccm.v13.i1.90746