Sepsis-induced mitochondrial dysfunction: A narrative review

Table 1 Different methods of mensuration of mitochondrial damage and recovery

Item	Description
Mitochondrial biogenesis	PPAR-γ coactivator 1-α, nuclear respiratory factor 1, mitochondrial transcription factor A. Material obtained from tissue biopsy or from peripheral PBMC
Mitochondrial content	Mitochondrial mass, concentration and area
Mitochondrial DNA content	PGC-1α, NRF-1, absolute DNA number of copies
Mitochondrial fusion	Mitofusins 1 and 2, optic atrophy 1 protein
Mitochondrial fission	Dynamin-related protein 1 and fission 1 protein

PPAR-γ: Peroxisome proliferator-activated receptor gamma; PGC-1α: Peroxisome proliferator-activated receptor gamma coactivator-1 alpha; NRF-1: Nuclear respiratory factor-1; PBMC: Peripheral blood mononuclear cells.