Extracorporeal blood purification strategies in sepsis and septic shock: An insight into recent advancements

Table 5 Studies determing oxiris efficacy for removal of endotoxins and cytokines

Ref.	Study type	Population	Intervention	Outcomes
Shum et al[98], 2013	Prospective case series with historical controls	6 patients with septic AKI	oXiris + CVVH	Significant reduction in SOFA scores by 37% after 48 h of therapy
Ugurov et al[96], 2020	Single centre case series	15 COVID -19 patients	oXiris hemofilter	Early initiation of oXiris was associated with stable or reducing levels of IL-6,8,10 and TNFα
Zhang et al[49], 2021	Case series	5 COVID-19 patients	CRRT followed by oXiris hemofilter therapy	Reduced levels of cytokines, haemodynamic stabilization and improvement of organ function was observed with oXiris.
Rosalia et al[100], 2020	Prospective cohort study	44 COVID 19 cases	CVVH + oXiris	Reduction in CRP, ferritin, fibrinogen and other inflammatory mediators were observed

COVID-19: Coronavirus disease 2019; CRRT: Continuous renal replacement therapy; SOFA: Sequential organ failure assessment; CRP: C-reactive protein; IL: Interleukin; CVVH: Continuous veno venous hemofiltration; TNFα: Tumornectrosis factor alpha.