Extracorporeal blood purification strategies in sepsis and septic shock: An insight into recent advancements

Table 4 Multiple logistic regression analysis to predict 30 d mortality

Feature	CytoSorb 300[84,85,86]	Jafron HA-series (80, 130, 180, 230, 280, 330, 380)[87]	Biosky MG-Series[88]
Manufacturer	CytoSorbents™ Inc, United States	Jafron Biomedical Co., Ltd. No. 98, Technology Sixth Road, High-tech Zone, Zhuhai City, 519085, Guangdong, China	Biosun Medical Technology Co. Ltd, China
IFU version	October 1, 2021[87]	11-Sep-19	1-Aug-18
Adsorbent	Crosslinked Divinylbenzene	Neutral Macroporous Resin	Medical Neutral Macroporous Synthetic Resin
Coating	Polyvinylpyrollidone	Collodion	No data
Adsorbent Surface	> 45000 m2	100000m2	No data
Storage fluid	Isotonic saline	Water for injection	Sterile water
Use time/cartridge	24 h, Can be administered up to 7 consecutive days	Depending on mode of operation: Hemoperfusion 100-250 mL/ min; Dialysis < 320 ml/ min with use upto 4 h; CRRT 150-250 mL/min with use upto 12 h; CPB up to 700 mL/ min with use upto 2.5 h	120-180 min, Not suggested to use more than 3 times within 24 h
Blood flow	100-700 mL/min, Recommended > 150 mL/min	100-700 mL/min	100-400 mL/min; Highest rate is 250 mL/min
Pmax	760 mmHg	750 mmHg	750 mmHg
Mode of operation covered	Hemoperfusion, Intermittent hemodialysis, CRRT, Cardiopulmonary bypass (CPB) ECMO	Hemoperfusion; Hemodialysis; CRRT; CPB	Hemoperfusion; Hemodialysis; CRRT; CPB only as comment in anticoagulation, not in setup
Shelf life	3 yr	2 yr	2 yr
Safety report status	As of 2021: > 162000 treatments distributed without confirmed serious device related events	No data	No data

IFU: Instructions for use; CRRT: Continuous renal replacement therapy; CPB: Cardiopulmonary bypass; ECMO: Extracorporeal membrane oxygenation.