Postoperative complications and critical care management after cytoreduction surgery and hyperthermic intraperitoneal chemotherapy: A systematic review of the literature

Table 2 Surgical complications

Ref.	N	Mortality (%)	Days	Morbidity (Grade III/IV), %	Complication classification	Commonest complications			Re-operations (%)
						First (%)	Second (%)	Third (%)
Cavaliere et al[35], 2011	146	2.7	30	27.4	WHO	GI perforation/anastomotic leak (7.4)	Sepsis (4.1)	Pancreatitis/pancreatic fistula (1.4)	NA
Glehen et al[36], 2010	1154, 190 (EPIC)	4.1	30	33.6	NCICTCAE	GI perforation/anastomotic leak (9.7)	Pneumonia (9.1)	Intraabdominal bleeding (7.7)	14
Cooksley et al[7], 2011	69	0	30	5.79	NA	Pneumonia (2.9)	Central line infection (1.5)	Uncontrolled hypertension (1.5)	NA
Mizumoto et al[37], 2012	284	3.5	30	17	NCICTCAE	GI perforation/anastomotic leak (6.7)	Sepsis (4.6)	Intraabdominal bleeding (2.1)	11
Bakrin et al[1], 2012	246	0.37	30	11.6	NCICTCAE	GI perforation/anastomotic leak (4.9)	Intraabdominal bleeding (2.4)		4.9
Baratti et al[17], 2012	426	2.6	90	25.3	NCICTCAE	GI perforation/anastomotic leak (11.03)	Sepsis (3.76)	Intraabdominal bleeding (3.3)	10.7
Bakrin et al[16], 2013	566	0.8	30	31.3	NCICTCAE	Intraabdominal bleeding (8)	GI perforation/anastomotic leak (3)		8
Canda et al[27], 2013	118	7.6	30	31.35	NCICTCAE	Sepsis (7.6)	Pneumonia (2.5)	Ileus (2.5)	5.08
Jafari et al[15], 2014	694	2.3	30	32.9	NA	Intraabdominal bleeding (17)	Sepsis (15.9)	Pneumonia (4.8)	9.8
Levine et al[30], 2014	1000	3.8	30	42	NA	Sepsis	GI perforation/anastomotic leak	Pneumonia	NA
Cascales-Campos et al[24], 2016	156	0.6	30	11.5	NCICTCAE	Pleural effusion (4.49)	Sepsis (3.8)	GI perforation/anastomotic leak (1.9)	NA
Martin et al[25], 2016	302	3	30		NA	Pleural effusion (10.8)	Thrombosis (6.8)	Sepsis (5.4)	NA
Elekonawo et al[38], 2019	223	1.5	30	17.6	Clavien Dindo	Sepsis (14.7)	GI perforation/anastomotic leak		NA
Kelly et al[39], 2018	226		30	NA	NA	Ileus (31)	Sepsis (21)	Thrombosis (15)	16

EPIC: Early postoperative intravenous chemotherapy; GI: Gastrointestinal; NA: Not available; NCICTCAE: National Cancer Institute Common Terminology Criteria for Adverse Events version 3.0 (NCICTCAE).