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©The Author(s) 2022.
World J Crit Care Med. Jul 9, 2022; 11(4): 269-297
Published online Jul 9, 2022. doi: 10.5492/wjccm.v11.i4.269
Published online Jul 9, 2022. doi: 10.5492/wjccm.v11.i4.269
Table 4 Summary of studies using corticosteroids in coronavirus disease 2019
Ref. | Patients | Treatment regimen | Population | Mortality2 | ICU administration | In-hospital stay | Secondary infections |
RECOVERY Collaborative Group et al[177], RCT | 11303 | DXM 6 mg daily × 10 d | In-hospital | Decrease 2.8% RR 0.83 | NS | Increase discharged 28 d (3.7%) | NA |
RECOVERY Collaborative Group et al[177], RCT | 1007 | DXM 6 mg daily × 10 d | MV | Decrease 12.1% RR 0.64 | NA | Increased discharged 28 d (9.7% RR 1.48) | NA |
Tomazini et al[176], RCT | 299 | DXM 20 mg × 5d + DXM 10 mg × 5d | ICU patients | Decrease 2.4% (alive or ventilator-free) | NA | DXM 21.9% vs 29.1% standard. (7.9% vs 9.5% bacteremia) | |
Jeronimo et al[178], RCT | 416 | MPD (0.5 mg/kg twice daily) × 5d | In-hospital | NS | NS (MV) | NS | No significant differences |
Dequin et al[179], RCT | 149 | HCT 200 mg daily × 7d then decrease dose × 7d (14 d) | ICU patients | NS | NS | NA | |
Angus et al[180], RCT | 384 | HCT 50 or 100 mg/6 h × 7 d | ICU patients | 93% and 80% of superiority in organ support free | NS | NA | |
Edalatifard et al[181], RCT | 68 | MPD 250 mg × 3 d | In-hospital | Decrease 37% | No patients on MV | Decrease 4.6 d | 2.9% (1 pt) in MPD vs 0% (0 pt) standard |
Corral-Gudino et al[188], RCT1 | 85 | MPD 40 mg/12 h × 3 d, then MPD 20 mg/12 h × 3 d | In-hospital | Decrease 24% composite death, ICU Adm or NIV | NS | NA | |
Kim et al[186], MA | 49569 | Variable regimens | ICU patients | OR 0.54 (0.40-0.73) | NA | NS | NA |
Van Paassen et al[187], MA | 20197 | Variable regimens | In- hospital | OR 0.72 (0.57-0.87) | RR 0.71 (0.54-0. 97) | NS | NA |
- Citation: Andaluz-Ojeda D, Vidal-Cortes P, Aparisi Sanz Á, Suberviola B, Del Río Carbajo L, Nogales Martín L, Prol Silva E, Nieto del Olmo J, Barberán J, Cusacovich I. Immunomodulatory therapy for the management of critically ill patients with COVID-19: A narrative review. World J Crit Care Med 2022; 11(4): 269-297
- URL: https://www.wjgnet.com/2220-3141/full/v11/i4/269.htm
- DOI: https://dx.doi.org/10.5492/wjccm.v11.i4.269