Surgical outcomes of pulmonary resection for lung cancer after neo-adjuvant treatment

Table 3 Intraoperative/postoperative outcomes overall and among propensity-score matched cohorts (results represent odds ratios unless otherwise indicated)

Characteristic	Unadjusted (95%CI)	P-value1	Risk-adjusted(95%CI)	P-value1	Propensity-score matched cohort3 (95%CI)	P-value1
30-d mortality (%)	3.72 (2.22-6.22)	< 0.0011	2.70 (1.54-4.72)	0.0011	1.63 (0.77-3.45)	0.197
Overall morbidity (%)	2.02 (1.50-2.74)	< 0.0011	1.53 (1.12-2.11)	0.0101	1.68 (1.08-2.62)	0.0211
Return to OR	2.09 (1.32-3.33)	0.0011	1.77 (1.08-2.90)	0.0231	3.37 (1.41-8.04)	0.0061
Cardiac complication	3.34 (1.67-6.70)	0.0011	3.11 (1.47-6.57)	0.0031	2.57 (0.79-8.30)	0.116
Shock/sepsis	1.90 (1.00-3.60)	0.0491	1.53 (0.78-3.02)	0.217	3.80 (1.05-13.80)	0.0431
Unplanned intubation	2.62 (1.71-4.02)	< 0.0011	2.03 (1.28-3.22)	0.0021	1.66 (0.88-3.14)	0.116
Bleeding transfusion	3.30 (3.15-5.06)	< 0.0011	1.72 (1.08-2.73)	0.0231	2.31 (1.17-4.58)	0.0161
Serious morbidity (%)	1.83 (1.30-2.58)	0.0011	1.55 (1.08-2.23)	0.0181	1.70 (1.02-2.85)	0.0421
Length of stay (d)2
Predicted difference in means	-0.02 (-0.38 to 0.35)	0.927	-0.93 (-1.32 to -0.55)	< 0.0011	-1.02 (-1.54 to -0.50)	< 0.0011
Prolonged length of stay (%)	0.96 (0.87-1.34)	0.815	0.67 (0.47-0.96)	0.0301	0.63 (0.41-0.97)	0.0371
Operative time (min)2
Predicted difference in means	30.5 (28.8-32.1)	< 0.0011	26.4 (24.7-28.1)	< 0.0011	29.0 (26.5-31.6)	< 0.0011
Prolonged operative time (%)	2.00 (1.52-2.62)	< 0.0011	1.81 (1.36-2.41)	< 0.0011	1.73 (1.17-2.57)	0.0061

¹Two-sided P-values < 0.05 considered statistically significant. Adjusted models controlled for age, being a current smoker within one year, hypertension requiring medication, > 10% loss of body weight in last 6 mo, steroid use for chronic condition, abnormal preoperative WBC, abnormal preoperative hematocrit, abnormal preoperative albumin, operative year, managing specialty, and type of surgery preformed;

²Modified Park tests corresponded to a Poisson distribution. Generalized linear models (family Poisson, link log) were used to model non-normally distributed continuous data, followed by post-estimation average marginal effects to attain predicted mean differences and 95%CI. Interpretation: Patients treated with neo-adjuvant therapy had average operative times that were longer than those of surgery-only patients by 29.0 min (95%CI: 26.5-31.6 min);

³Separate cohorts were generated for each outcome using propensity-score-based 1:1 nearest-neighbor matching without replacement, accounting for significant baseline differences in demographic and clinical characteristics. OR: Operating room.