Surgical outcomes of pulmonary resection for lung cancer after neo-adjuvant treatment

Table 2 Unadjusted intraoperative and postoperative complications

Characteristic	Total n = 4063	Neoadjuvant patients n = 236 (5.81%)	Surgery-only patients n = 3827 (94.19%)	P-value1
30-d mortality (%)	107 (2.63)	19 (8.05)	88 (2.30)	< 0.0012
Overall morbidity (%)	646 (15.90)	63 (26.69)	583 (15.23)	< 0.0012
Wound infection	4 (0.10)	0 (0.00)	4 (0.10)	0.787
Pneumonia	5 (0.73)	0 (0.00)	5 (0.77)	0.774
Urinary tract infection	1 (0.15)	0 (0.00)	1 (0.16)	0.956
Return to OR	201 (4.95)	22 (9.32)	179 (4.68)	< 0.0012
Venous thromboembolism	80 (1.97)	7 (2.97)	73 (1.91)	0.256
Cardiac complication	60 (1.48)	10 (4.24)	50 (1.31)	< 0.0012
Shock/sepsis	107 (2.63)	11 (4.66)	96 (2.51)	0.0452
Unplanned intubation	207 (5.09)	27 (11.44)	180 (4.70)	< 0.0012
Bleeding transfusion	178 (4.38)	28 (11.86)	150 (3.92)	<0.0012
Renal complication	22 (0.54)	0 (0.00)	22 (0.57)	0.636
On ventilator > 48 h	3 (0.07)	1 (0.42)	2 (0.05)	0.164
Organ space SSI	44 (1.08)	1 (0.42)	43 (1.12)	0.516
Serious morbidity (%)	469 (11.54)	44 (18.64)	425 (11.11)	< 0.0012
Length of stay (d), median (IQR)	6 (4-9)	6 (4-9)	6 (4-8)	0.915
Prolonged length of stay (%)	816 (20.08)	46 (19.49)	770 (20.12)	0.815
Operative time (min), median (IQR)	161 (123-216)	160 (121-214)	192 (147-250)	< 0.0012
Prolonged operative time (%)	1006 (24.76)	91 (38.56)	915 (23.91)	< 0.0012

¹P-values taken from χ² tests (Fisher’s exact test in cell counts less than five);

²Two-sided values < 0.05 considered statistically significant. Wilcoxon rank-sum tests used to compare rank sum differences in non-normal distributions of length of stay and operative time. Overall morbidity: Wound infection, pneumonia, urinary tract infection, venous thromboembolism, bleeding transfusion, renal complication, return to OR, cardiac complication, shock/sepsis, unplanned intubation, on ventilator > 48 h, and organ space SSI. Serious morbidity: Return to OR, cardiac complication, shock/sepsis, unplanned intubation, on ventilator > 48 h, and organ space SSI. Prolonged length of stay and operative time refer to times longer than the 75^th percentiles for the respective distributions; IQR: Interquartile range; SSI: Surgical site infection; OR: Operating room.