Surgical outcomes of pulmonary resection for lung cancer after neo-adjuvant treatment

Table 1 Baseline demographic and clinical characteristics

Characteristic	Total n = 4063	Neoadjuvant patients n = 236 (5.81%)	Surgery-only patients n = 3827 (94.19%)	P-value1
Age (yr), median (IQR)	68 (61-75)	66 (55-72)	69 (61-75)	< 0.0012
Male (%)	2003 (49.30)	125 (52.97)	1878 (49.07)	0.246
Race (%)
White	3019 (74.30)	189 (80.08)	2830 (73.95)	0.173
Black	222 (5.46)	12 (5.08)	210 (5.49)
Latino(a)	432 (10.63)	17 (7.20)	415 (10.84)
Other or unknown	390 (9.60)	18 (7.63)	372 (9.72)
ASA classification (%)
1-2 no-mild disturbance	769 (18.97)	38 (16.24)	731 (19.14)	0.523
3 serious disturbance	2888 (71.24)	171 (73.08)	2717 (71.13)
4-5 life threatening/moribund	397 (9.79)	25 (10.68)	372 (9.74)
Functional status
Independent	3985 (98.08)	229 (97.03)	3756 (98.14)	0.227
Partially/totally dependent	78 (1.92)	7 (2.97)	71 (1.86)
Obese, BMI ≥ 30 (%)	1155 (28.65)	58 (24.79)	1097 (28.88)	0.178
Diabetes (%)	598 (14.72)	27 (11.44)	571 (14.92)	0.143
Current smoker (%)	1448 (35.64)	114 (48.31)	1334 (34.86)	< 0.0012
Alcohol consumption (%)	221 (5.44)	15 (6.36)	206 (5.38)	0.522
Dyspnea (%)	1106 (27.22)	57 (24.15)	1049 (27.41)	0.275
History of COPD (%)	1082 (26.63)	54 (22.88)	1028 (26.86)	0.179
History of heart disease (%)	42 (1.03)	3 (1.27)	39 (1.02)	0.734
Hypertension (%)	2375 (58.45)	111 (47.03)	2264 (59.16)	< 0.0012
Previous cardiac surgery (%)	308 (7.58)	11 (4.66)	297 (7.76)	0.081
Weight loss (%)	152 (3.74)	16 (6.78)	136 (3.55)	0.0112
Steroid use (%)	161 (3.96)	22 (9.32)	139 (3.63)	< 0.0012
Year of operation (%)
2005-2008	834 (20.53)	53 (22.46)	781 (20.41)	0.662
2009-2010	1794 (44.15)	105 (44.49)	1689 (44.13)
2011-2012	1435 (35.32)	78 (33.05)	1357 (35.46)
Preoperative WBC (%)
Normal (4.5-11.0 × 109/L)	3364 (85.88)	174 (74.36)	3190 (86.61)	< 0.0012
Abnormal (< 4.5 or > 11.0 × 109/L)	553 (14.12)	60 (25.64)	493 (13.39)
Preoperative hematocrit (%)
Normal (≥ 36)	3147 (80.53)	110 (47.01)	3037 (82.66)	< 0.0012
Abnormal (< 36)	761 (19.47)	124 (52.99)	637 (17.34)
Surgery type (%)
VATS	1203 (29.61)	34 (14.41)	1169 (30.55)	< 0.0012
Open	2860 (70.39)	202 (85.59)	2658 (69.45)

¹P-values taken from χ² tests (Fisher’s exact test in cell counts less than five);

²Two-sided values < 0.05 considered statistically significant. Wilcoxon rank-sum test used to compare rank sum differences in the non-normal distribution of age. Different denominators due to missing data: ASA (n = 4054); obese (n = 4032); WBC (n = 3917), hematocrit (n = 3908). ASA: American Society of Anesthesiology; COPD: Chronic obstructive pulmonary disease; WBC: White blood cell (count); VATS: Video-assisted thoracic surgery; BMI: Body mass index; IQR: Interquartile range.