Regulatory T cells suppress autoreactive CD4+ T cell response to bladder epithelial antigen

Figure 1 Animal crossbreeding. URO-OVA/OT-II mice were generated through crossbreeding of URO-OVA mice with OT-II mice. B6/OT-II mice were generated through crossbreeding of B6 mice with OT-II mice. URO-OVA^GFP-Foxp3 mice were generated through crossbreeding of URO-OVA mice with Foxp3^gfp mice. B6^GFP-Foxp3 mice were generated through crossbreeding of B6 mice with Foxp3^gfp mice. Both URO-OVA^GFP-Foxp3 and B6^GFP-Foxp3 mice were further crossed with OT-II mice to generate URO-OVA^GFP-Foxp3/OT-II and B6^GFP-Foxp3/OT-II mice, respectively. URO: Urothelium; OVA: Ovalbumin.