Chimeric antigen receptors: On the road to realising their full potential

Figure 2 The overview of manufacture of chimeric antigen receptor T-cell products. A: Starting material is most commonly a leukapheresis, although some systems employ whole blood at this stage; B: Peripheral blood mononuclear cells are isolated and T-cells then activated and genetically engineered (in this case with a viral vector); C: After ex-vivo expansion, the cell product is formulated and administered; D: After which engineered cells can engage target cells via the CAR. CAR: Chimeric antigen receptor.