Lessons from Sjögren’s syndrome etiopathogenesis: Novel cellular and molecular targets

Figure 2 T cells and B cells are recruited into exocrine glands where they mount a chronic inflammatory response. Local production of IL-1β and type I interferons (IFN) by epithelial cells and innate immune cells contributes to local inflammation and promotes apoptosis of acinar cells. Clones of activated T cells with varied effector differentiation support local inflammation and contribute to acinar destruction. IL: Interleukin; BAFF: B cell activating factor.