Dendritic cells and the extracellular matrix: A challenge for maintaining tolerance/homeostasis

Figure 7 Immunohistochemistry image of biointeractive RHCIII hydrogel in a lamellar keratoplasty and removed after 4 years, upon regrafting of the patient. Notably, regrowth of characteristically stratified corneal epithelium (ep), layered stroma (s) and endothelial monolayer (en) left intact during transplantation, can be observed (A). A portion of the RHCIII implant (i) is visible in a higher magnification image (B), displaying a uniform assimilation with the native stroma in a dynamic, ongoing remodelling process. Reprinted from Fagerholm P, Lagali NS, Ong JA, Merrett K, Jackson WB, Polarek JW, Suuronen EJ, Liu Y, Brunette I, Griffith M. Stable corneal regeneration four years after implantation of a cell-free recombinant human collagen scaffold. Biomaterials 2014; 35: 2420-2427. Copyright (2014), with permission from Elsevier.