Present and future of immune checkpoint blockade: Monotherapy to adjuvant approaches

Table 3 Ongoing clinical Trials in combination anti-programmed death-1 and anti-cytotoxic T lymphocyte associated antigen-4 Blockade

Identifier	Phase	Cancer type	Checkpoint antibodies	Status
NCT02060188	2	Microsatellite High (MSI-H) Colon Cancer	Nivolumab, ipilimumab	Recruiting
NCT01454102	1	NSCLC	Nivolumab, ipilimumab	Recruiting
NCT01472081	1	RCC	Nivolumab, ipilimumab	Recruiting
NCT01024231	1b	Melanoma	MDX-1106, ipilimumab	Active
NCT01928394	1/2	TNBC, GC, PC, SCLC, BC	Nivolumab, ipilimumab	Recruiting
NCT02017717	2b	GBM	Nivolumab, ipilimumab	Recruiting
NCT01927419	2	Melanoma	Nivolumab, ipilimumab	Active
NCT01844505	3	Melanoma	Nivolumab, ipilimumab	Active
NCT01592370	1	Hematologic malignancy	Nivolumab, ipilimumab	Recruiting
NCT01783938	2	Melanoma	Nivolumab1, ipilimumab	Recruiting

¹Nivolumab is sequentially dosed with Ipilimumab in this study, whereas in all other studies it is concurrently dosed. Identifier refers to Clinicaltrials.gov identifier. NSCLC: Non-small cell lung cancer; RCC: Renal cell carcinoma; TNBC: Triple negative breast cancer; GC: Gastric cancer; PC: Pancreatic cancer; SCLC: Small cell lung cancer; BC: Bladder cancer; GBM: Glioblastoma.