Lysosomal acid lipase is critical for myeloid-derived suppressive cell differentiation, development, and homeostasis

Figure 3 Lysosomal acid lipase is required for normal T cell development and differentiation. Lysosomal acid lipase (LAL) deficiency can cause the intrinsic defect in T cell development, starting at the double negative 3 (DN3) stage. In addition, myeloid-derived suppressive cells infiltrate into the thymus and spleen, resulting in blockage of normal T cell development, differentiation, and maturation. DN: CD4 and CD8 double negative; DP: CD4 and CD8 double positive; SP: CD4 or CD8 single positive.