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Figure 3 Lysosomal acid lipase is required for normal T cell development and differentiation.
Lysosomal acid lipase (LAL) deficiency can cause the intrinsic defect in T cell development, starting at the double negative 3 (DN3) stage. In addition, myeloid-derived suppressive cells infiltrate into the thymus and spleen, resulting in blockage of normal T cell development, differentiation, and maturation. DN: CD4 and CD8 double negative; DP: CD4 and CD8 double positive; SP: CD4 or CD8 single positive.
- Citation: Yan C, Du H. Lysosomal acid lipase is critical for myeloid-derived suppressive cell differentiation, development, and homeostasis. World J Immunol 2014; 4(2): 42-51
- URL: https://www.wjgnet.com/2219-2824/full/v4/i2/42.htm
- DOI: https://dx.doi.org/10.5411/wji.v4.i2.42