Lysosomal acid lipase is critical for myeloid-derived suppressive cell differentiation, development, and homeostasis

Figure 2 Lysosomal acid lipase is required for normal myeloid lineage cell development and differentiation. Lysosomal acid lipase (LAL) deficiency leads to increased myeloid-derived suppressive cells differentiation from Lin^- progenitor cells in the bone barrow, and decreased differentiation to mature macrophages, neutrophils, and dendritic cells in other compartments. Lin^-: Lineage negative progenitor; CMP: Common myeloid progenitor; GMP: Granulocyte-macrophage progenitor; Mac: Macrophage; PMN: Polymorphonuclear cell, or neutrophil; DC: Dendritic cell.