Lysosomal acid lipase is critical for myeloid-derived suppressive cell differentiation, development, and homeostasis

Figure 1 The functional role of Lysosomal acid lipase in myeloid lineage cells. In the wild type mice, the CD11b⁺Ly6G⁺ cells are myeloid lineage precursors for monocytes/macrophages, neutrophils, and dendritic cells, which participate in the normal physiological functions of the distal organs (e.g., lung, liver, etc.), such as clearance of invading pathogens. The lysosomal acid lipase (LAL) activity is essential for normal myeloid lineage cell development, differentiation and function. LAL deficiency leads to neutral lipid accumulation in myeloid cells and blocks CD11b⁺Ly6G⁺ cells from further differentiation into mature myeloid lineage cells. The accumulated CD11b⁺Ly6G⁺ cells possess various malfunctions that participate in the pathogenic conditions in the residing organs. MDSCs: Myeloid-derived suppressive cells.