Role of IL28B genotype in older hepatitis C virus-infected patients

doi:10.5411/wji.v3.i3.54

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World Journal of Immunology

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2219-2824

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Immunol. Nov 27, 2013; 3(3): 54-61
Published online Nov 27, 2013. doi: 10.5411/wji.v3.i3.54

Table 4 Association between IL28B rs8099917 and treatment response in hepatitis C patients aged ≥ 65 years and treated with standard of care

	Total	IL28B TT	IL28B TG	¹P values
	(n = 41)	(n = 31)	(n = 10)
Age (yr)	67.7 ± 2.6	68.0 ± 2.9	67.0 ± 1.3	0.141
Gender (male/female)	28/13	22/9	4/6	0.796
HCV viral load, (high/low)	41/0	31/0	10/0	NA
HCV genotype (G1/G2)	41/0	25/6	8/2	0.678
Treatment-naïve (yes/no)	29/12	24/7	5/5	0.208
ALT (IU/L)	56.5 ± 40.2	54.9 ± 41.2	61.1 ± 38.9	0.677
γ-GTP (IU/L)	36.4 ± 33.3	33.1 ± 33.1	46.6 ± 33.4	0.269
White blood cells (/μL)	4840 ± 1300	4730 ± 1160	5190 ± 1690	0.337
Hemoglobin (g/dL)	13.5 ± 1.3	13.6 ± 1.1	13.3 ± 1.8	0.528
Platelets (x104/μL)	14.9 ± 5.4	14.4 ± 5.1	16.5 ± 6.2	0.289
IL28B rs8099917 (TT/TG)	31/10	31/0	0/10	NA
EVR rates	34.1% (14/41)	45.1% (14/31)	0% (0/10)	0.025
SVR rates	43.9% (18/41)	48.3% (15/31)	30.0% (3/10)	0.514

Values are expressed as mean ± SD. ¹P value, comparison between IL28B TT and IL28B TG groups. HCV: Hepatitis C virus; ALT: Alanine aminotransferase; γ-GTP: γ-glutamyl transpeptidase; EVR: Early virological response; SVR: Sustained virological response; NA: Not available.

Citation: Kanda T, Nakamoto S, Wu S, Yokosuka O. Role of IL28B genotype in older hepatitis C virus-infected patients. World J Immunol 2013; 3(3): 54-61
URL: https://www.wjgnet.com/2219-2824/full/v3/i3/54.htm
DOI: https://dx.doi.org/10.5411/wji.v3.i3.54