Eotaxin-2 blockade ameliorates experimental autoimmune encephalomyelitis

Figure 2 The effect of anti-eo-2 neutralizing mAb treatment on the level of anti-MOG_35-55 autoantibodies in experimental autoimmune encephalomyelitis sera. Experimental autoimmune encephalomyelitis (EAE) mice daily treated with PBS, total mouse IgG, 25 μg or 100 μg D8, were sacrificed on day 58 and their sera were assessed for the presence of anti-myelin oligodendrocyte glycoprotein (anti-MOG) autoantibodies using ELISA. No significant effect in the level of anti-MOG IgG antibodies was accepted in both D8 treated groups compared to the IgG treated group (values presented are A₄₅₀ nm, n = 9 in each group).