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©The Author(s) 2022.
World J Immunol. Jan 24, 2022; 12(1): 1-8
Published online Jan 24, 2022. doi: 10.5411/wji.v12.i1.1
Published online Jan 24, 2022. doi: 10.5411/wji.v12.i1.1
IgSF co-stimulatory molecules | Function | Cells expressing the receptor | Ligand | Cells expressing the ligand |
CD28 | Activation | Constitutive in T cells | CD80, CD86 | CD80: Inducible in dendritic cells, monocytes, B and T cells. CD86: Constitutive in dendritic cells, monocytes, B and T cells |
ICOS (CD278) | Activation | Inducible in T, B, and NK cells | ICOSL | Constitutive in macrophages, dendritic cells, B and T cells |
CTLA-4 (CD152) | Inhibition | Inducible in T cells | CD80, CD86 | CD80: Inducible in dendritic cells, monocytes, B and T cells. CD86: Constitutive in dendritic cells, monocytes, B and T cells |
PD-1 (CD279) | Inhibition | Inducible in T, and B cells, macrophages | PD-L1, PD-L2 | PD-L1: Constitutive in dendritic cells, B and T cells. PD-L2: Inducible in dendritic cells and monocytes |
PD-1H (VISTA) | Inhibition | Monocytes, neutrophils, T cells | Unknown | Unknown |
BTLA (CD272) | Inhibition | B and T cells | HVEM, UL144 | Monocytes, B and T cells |
B71 (CD80), B72 (CD86) | Activation/Inhibition | CD80: Inducible in dendritic cells, monocytes, B and T cells. CD86: Constitutive in dendritic cells, monocytes, B and T cells | CD28, CTLA-4 | CD28: Constitutive in T cells. CTLA-4: Inducible in T cells |
B7H1 (CD274, PDL1) | Inhibition | Constitutive in dendritic cells, monocytes, B and T cells | PD-1, B71 | PD-1: Inducible in macrophages, B and T cells. CD80: Inducible in dendritic cells, monocytes, B and T cells |
- Citation: Velazquez-Soto H, Real F, Jiménez-Martínez MC. Historical evolution, overview, and therapeutic manipulation of co-stimulatory molecules. World J Immunol 2022; 12(1): 1-8
- URL: https://www.wjgnet.com/2219-2824/full/v12/i1/1.htm
- DOI: https://dx.doi.org/10.5411/wji.v12.i1.1