Adjuvant radiotherapy for pathologically advanced prostate cancer improves biochemical recurrence free survival compared to salvage radiotherapy

Table 2 Stepwise cox regression multivariate analysis

		Biochemical recurrence		Overall survival		Bone metastases		Hormonal therapy
		HR (95%CI)	P value	HR (95%CI)	P value	HR (95%CI)	P value	HR (95%CI)	P value
Pathologic gleason score	2-6	Referent	0.01	Referent	0.4	Referent	0.3	Referent	0.005
	7	1.2 (0.4-3.1)	0.8		0.7		0.9	1.2 (0.3-4.6)	0.8
	8-10	3.1 (1.2-8.1)	0.02		0.2		0.1	4.9 (1.4-16.7)	0.01
Pre-RT PSA	Undetectable	Referent	< 0.001	Referent	0.8	Referent	0.045	Referent	< 0.001
	> 0.0-0.2	4.1 (1.5 -11.2)	0.005		0.8	3.3 (0.2-54.2)	0.4	2.6 (0.8-9.1)	0.1
	> 0.2-1.0	4.4 (1.6-11.9)	0.003		0.6	0.6 (0.04-8.6)	0.7	1.7 (0.5-5.8)	0.4
	> 1.0	52 (12.9-210)	< 0.001		0.7	39.8 (1.8-868)	0.02	67.8 (13.7-336)	< 0.001
Received peri-RT ADT			0.7		0.2		0.1		0.6
Seminal vesicle invasion		2.2 (0.99-4.8)	0.053		0.9		0.2	2.7 (1.1-6.6)	0.036
Positive surgical margin			0.056		0.08		0.08		0.09
Extracapsular extension			0.3		0.1		0.6		0.6
Pathologic stage	T2	Referent	0.9	Referent	0.1	Referent	0.9	Referent	0.8
	T3/4

RT: Radiotherapy; PSA: Prostate specific antigen; ADT: Androgen deprivation therapy; CI: Confidence interval.