Development of a nomogram for predicting a positive repeat prostate biopsy

Table 2 Association between cancer detection rates and clinical variables according to the number of biopsy sessions

Variable	Total No./No. Ca (%)
	Biopsy 2	Biopsy 3	Biopsy 4	Biopsy 5
	459/75(16.3)	208/34 (16.7)	82/15(18)	41/3(7)
Digital rectal examination
Negative	437/73 (16.7)	195/29(14.9)	76/12 (15.8)	40/3 (7.5)
Positive	22/2 (9.1)	13/5(38.5)	6/3 (50)	1/0 (0)
Prostate volume on TRUS, (cc)
Less than 20	15/7 (47.7)	6/4 (66.7)	0/0 (0)	0/0 (0)
20-40	181/39 (21.5)	69/12 (17.4)	24/6 (25.0)	14/1 (7.1)
40-60	145/19 (13.1)	75/12 (16.0)	35/5 (14.3)	16/2 (12.5)
60-80	71/7 (9.9)	32/6 (18.8)	13/2 (15.4)	5/0 (0)
80 or Greater	47/3 (6.3)	26/0 (0)	10/2 (20.0)	6/0 (0)
PSA density (ng/mL per cc)
Less than 0.15	196/16 (8.2)	82/11 (13.4)	29/6 (20.7)	10/0 (0)
0.15-0.30	185/33 (17.8)	84/10 (11.9)	36/6 (16.7)	22/3 (13.6)
0.30-0.45	46/14 (30.4)	20/3 (15.0)	10/1 (10.0)	7/0 (0)
Greater than 0.45	32/12 (38.5)	22/10 (45.5)	7/2 (28.6)	2/0 (0)
PSA TZ density (ng/mL per cc)
Less than 0.25	156/9 (5.8)	58/7 (12.1)	19/3 (18.8)	10/0 (0)
0.25-0.5	168/22 (13.1)	85/11 (12.9)	42/7 (16.7)	18/2 (22.2)
0.5-1.0	98/26 (26.5)	40/6 (15.0)	15/3 (20.0)	12/2 (18.3)
Greater than 1.0	37/18 (48.6)	25/10 (40.0)	6/2 (33.3)	1/0 (0)
PSA (ng/mL)
Less than 4	18/1 (5.6)	1/1 (100)	0/0 (0)	0/0 (0)
4-10	313/48 (15.3)	136/19 (14.0)	49/8 (16.3)	20/2 (10.0)
10-20	108/21 (19.4)	54/11 (20.3)	25/5 (20.0)	17/1 (5.9)
Greater than 20	20/5 (25.0)	17/3 (17.6)	8/2 (25.0)	4/0 (0)
PSA slope (ng/mL per year)
Less than 0.75	237/30 (12.7)	102/15 (14.7)	44/8 (18.2)	21/1 (4.8)
0.75 or greater	222/45 (20.3)	106/19 (17.9)	38/7 (18.4)	20/2 (10.0)
Previous HGPIN
Negative	437/67 (15.3)	200/32 (16.0)	79/14 (17.7)	40/3 (7.5)
Positive	22/8 (36.4)	8/2 (25.0)	3/1 (33.3)	1/0 (0)
Previous ASAP
Negative	427/68 (15.9)	190/30 (15.8)	75/13 (17.3)	38/2 (5.3)
Positive	32/7 (21.9)	18/4 (22.2)	7/2 (28.6)	3/1 (33.3)
Normal histology	406/61 (15.0)	184/29 (15.8)	72/12 (16.7)	37/2 (5.4)
Total	459/75 (16.3)	208/34 (16.4)	82/15 (18.3)	41/3 (7.3)

Results of cases with 6 or more biopsy sessions are not shown because of low numbers. HGPIN: High grade prostatic intraepithelial neoplasia; TZ: Transitional zone; ASAP: Atypical small acinar proliferation.