Systematic review of the non surgical management of Peyronie's disease

Table 1 Efficacy of non surgical treatments on Peyronie’s disease

Therapy	Therapeutic activity and indication
Oral treatment with potassium para- aminobenzoate	Reduction in penile plaque size and penile pain as well as penile curvature stabilization
Oral treatment with vitamin E and tamoxifen	Not associated with significant reduction in penile curvature, plaque size or penile pain
Other oral treatments (acetyl esters of carnitine, pentoxifylline)	Not recommended
Intralesional treatment with verapamil	No statistically significant differences in plaque size, penile curvature, penile pain
Intralesional treatment with steroids	Not associated with significant reduction in penile curvature, plaque size or penile pain
Intralesional treatment with interferon	Improve Penile curvature, plaque size and density, and pain
Intralesional treatment with clostridial collagenase	Significant decreases in the deviation angle, plaque width and plaque length
Iontophoresis with verapamil 5 mg and dexamethasone 8 mg	Improve penile curvature and plaque size
Extracorporeal shock-wave treatment	Beneficial for penile pain and stabilization of plaque
Topical verapamil gel 15%	Improve penile curvature and plaque size
Penile traction devices and vacuum devices	Reduce penile deformity and increase penile length
Combination therapies	Preliminary evidences to be clarified