Prevention of necrotizing enterocolitis in premature infants – an updated review

Table 3 Summary of five randomized controlled trials of prophylactic antibiotics on the risk of necrotizing enterocolitis

Ref.	Yr	GA	BW	N	Study	NEC ≥ stage II, %			Mortality, %			LOS, (%)
						Study	Control	P < 0.05	Study	Control	P < 0.05	Study	Control	P < 0.05
Tagare et al[47]	2010	< 37	-	140	Amoxicillin clavulanic acid and amikacin	13.0	4.2	Yes	2.9	2.8	No	1.4	14.1	Yes
Kenyon et al[48]	2002	< 37	-	4809	Co-amoxiclav	1.6	0.3	Yes	5.7	6.2	No	6.2	7.9	No
Oei et al[49]	2001	≤ 32	-	43	Erythromycin	4.5	4.8	No	4.5	4.8	No	-	-	-
Siu et al[50]	1998	-	< 1500	140	Vancomycin	12.7	27.5	Yes	15.5	18.8	No	-	-	-
Owen et al[51]	1993	24-33	-	117	Ampicillin	14	3.5	Yes	6.8	12	No	3.4	10	No

BW: Birth weight; LOS: Late onset sepsis; NEC: Necrotizing enterocolitis.