Conversion from prolonged intravenous fentanyl infusion to enteral methadone in critically ill children

Table 3 Clinical outcomes in rapid and slow conversion groups

	Rapid conversion groupa (n = 21)	Slow conversion groupb (n = 21)	P value
Ventilator free days at 28 d, d (median, IQR)	18 (13.3-18.8)	8 (1.5-10.8)	< 0.05
Total PICU length of stay, d (median, IQR)	17 (12-24)	38.5 (24.8-68.5)	0.05

^aRapid conversion group: Patients who were completely converted from IV fentanyl infusion directly to enteral methadone in 48 h or less;

^bSlow conversion group: Patients who were completely converted from IV fentanyl infusion directly to enteral methadone in more than 48 h. IQR: Inter-quartile range; PICU: Pediatric intensive care unit.