Spectrum of complicated migraine in children: A common profile in aid to clinical diagnosis

Table 6 List the select reports of the use of multimodaility and their results primarily in children with prolonged hemiplegic migraine[42-45]

Neuroimaging type and the clinical conditions	Study revealed
Multimodality neuroimaging in a single familial hemiplegic migraine[42]	Cytotoxic edema along with evidence of hypometabolism but no evidence of hypoperfusion of the affected cerebral hemisphere
Perfusion- and susceptibility-weighted imaging in a 13-year-old-female 3 h after the right hemiplegia[43]	Hypoperfusion in the left cerebral hemisphere and a matching prominent hypotensity, respectively. Diffusion tensor imaging sequences were normal. These abnormalities completely resolved 24 h after the attack onset
Perfusion- and diffusion-weighted MRI during visual auras in four migraineurs[44]	Cerebral blood flow and volume, both decreased by 16%-53% and 6%-33%, respectively. Mean transit time in the affected occipital cortex was increased by 10%-54%. No changes in the diffusion coefficient were observed during and after the resolution of the visual aura
Brain MRI in six population and 13 clinic-based meta-analysis studies in migraines with and without aura[45]	White matter abnormalities, silent infarct-like lesions, and volumetric changes in both gray and white matter regions were more common in migraineurs than in control groups. These data suggest that migraine may be a risk factor for structural changes in the brain

Some of these conflicting reports support the clinically observed variability in the manifestation of the migraine. MRI: Magnetic resonance imaging.