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World J Clin Pediatr. Aug 8, 2014; 3(3): 45-53
Published online Aug 8, 2014. doi: 10.5409/wjcp.v3.i3.45
Published online Aug 8, 2014. doi: 10.5409/wjcp.v3.i3.45
Antiepileptic | Effect on sleep |
Benzodiazepines and barbiturates[70,71] | Reduce sleep latency Decrease the amount of REM sleep Benzodiazepines reduce slow wave sleep Increase incidence of OSA |
Phenytoin[70,72,73] | Increases light sleep Decreases sleep efficiency Most studies show decreased REM sleep |
Ethosuximide | May cause sleep disturbances, and night terrors |
Carbamazepine[72,74,75] | Reduction in REM sleep particularly with acute treatment Effective in treatment of restless legs syndrome sleep disorder |
Valproate[73] | May increase stage 1 sleep Could worsen OSA through weight gain |
Lamotrigine[75,76] | May cause decreases in slow wave sleep May cause insomnia and sleep disturbance Effective in treatment of restless legs syndrome |
Gabapentin, pregabalin, and tiagabine[76-81] | Enhance slow wave sleep and sleep continuity Gabapentin is effective in treatment of restless legs syndrome Pregabalin may cause insomnia and abnormal dreams |
Levetiracetam[79,80] | Has little effect or an increase in sleep continuity and slow wave sleep |
Zonisamide, rufinamide, oxcarbazepine, and topiramate[82,83] | Have no known effects on sleep and sleep disorders May cause insomnia |
- Citation: Al-Biltagi MA. Childhood epilepsy and sleep. World J Clin Pediatr 2014; 3(3): 45-53
- URL: https://www.wjgnet.com/2219-2808/full/v3/i3/45.htm
- DOI: https://dx.doi.org/10.5409/wjcp.v3.i3.45