Importance of celiac disease oral manifestations in pediatric patients: A systematic review

Table 3 Methodological critical appraisal of case-control studies

Ref.	Q1	Q2	Q3	Q4	Q5	Q6	Q7	Q8	Q9	Q10	N yes
Alsadat et al[11], 2021	Yes	Yes	Yes	Yes	Yes	Yes	Unclear	Yes	Not applicable	Yes	8
Shahraki et al[7], 2019	Yes	Yes	Yes	Yes	Yes	Yes	Unclear	Yes	Not applicable	Yes	8
Alamoudi et al[23], 2020	Yes	Yes	No	Yes	Yes	Unclear	Unclear	Yes	Not applicable	Yes	6
Macho et al[22], 2020	Yes	Yes	Yes	Unclear	Unclear	Yes	Yes	Yes	Yes	Yes	8
Macho et al[9], 2019	Yes	Yes	Yes	Unclear	Unclear	Unclear	Unclear	Yes	Yes	Yes	6
Zoumpoulakis et al[19], 2019	Yes	Yes	Yes	Unclear	Unclear	Yes	Unclear	Yes	Not applicable	Yes	6
de Carvalho et al[20], 2015	Yes	Yes	Yes	Unclear	Unclear	Yes	Unclear	Yes	Not applicable	Yes	6
Cantekin et al[21], 2015	Yes	Yes	Yes	Unclear	Unclear	Yes	Unclear	Yes	Not applicable	Yes	6

Q1: Are the two groups comparable? Q2: Were the cases and controls appropriately matched? Q3: Were the same criteria used to identify cases and controls? Q4: Was the exposure measured in a valid and reliable way? Q5: Was the exposure measured the same way for cases and controls? Q6: Were confounding factors identified? Q7: Were strategies to deal with confounding factors indicated? Q8: Were the outcomes measured in a valid and reliable way for both cases and controls? Q9: Was the exposure period long enough to be significant? Q10: Was appropriate statistical analysis used?