Clinical, laboratory, and therapeutic differences between immunoglobulin E-mediated and non-immunoglobulin E-mediated cow’s milk protein allergy in children

Table 3 Laboratory findings in children with cow’s milk protein allergy, n (%)

Laboratory findings	Result/total tested, n = 595 (100)	IgE-mediated, n = 135 (22.7)	Non-IgE-mediated, n = 460 (77.3)	P valuea
Anemia	424/563 (75.3)	102 (77.3)	322 (74.7)	0.645
Low hematocrit	153/476 (32.1)	31 (26.3)	122 (34.1)	0.139
Low mean corpuscular volume	334/484 (69.0)	89 (73.0)	245 (67.7)	0.309
Low mean corpuscular hemoglobin	376/484 (77.7)	96 (78.7)	280 (77.3)	0.803
Low iron	153/279 (54.8)	42 (48.8)	111 (57.5)	0.194
Low ferritin	29/69 (42.0)	9 (45.0)	20 (40.8)	0.793
Thrombocytosis	229/483 (47.4)	53 (43.4)	176 (48.8)	0.473
Leukocytosis	199/477 (41.7)	46 (39.0)	153 (42.6)	0.520
Vitamin D deficiency	82/271 (30.3)	23 (26.4)	59 (32.1)	0.397
Low albumin	41/223 (18.4)	10 (19.6)	31 (18.0)	0.838
High alkaline phosphatase	49/368 (13.3)	15 (15.8)	34 (12.5)	0.483
Hypocalcemia	19/320 (5.9)	7 (8.0)	12 (5.2)	0.426
Eosinophilia	20/476 (4.2)	5 (4.2)	15 (4.2)	1.000
Hypophosphatemia	5/332 (1.5)	3 (3.1)	2 (0.8)	0.147
High milk-specific IgE	121/240 (50.4)	121 (97.6)	0 (0.0)	< 0.001

Data are presented as numbers and percentages. Boldface indicates a statistically significant difference with P < 0.05.

^aFisher’s exact test.

IgE: Immunoglobulin E.