Clinical and laboratory features of juvenile idiopathic arthritis with wrist involvement: Results of a retrospective cohort study

Table 2 Factors associated with wrist involvement in juvenile idiopathic arthritis patients

Parameter	Se	Sp	OR (95%CI)	P value
Sex, female	43.9	73.0	2.1 (1.5-3.0)	0.00002
Systemic JIA	16.7	95.6	4.4 (2.5-7.6)	0.0000001
Uveitis	89.1	26.4	0.43 (0.21-0.91)	0.0002
Active joints > 9	69.6	81.1	9.8 (6.8-14.1)	0.000001
Height ≤ 39%	47.1	65.0	1.7 (1.1-2.5)	0.011
BMI ≤ -0.3 SD	49.7	64.1	1.8 (1.2-2.6)	0.004
CRP > 5.9 mg/L	41.0	76.0	2.2 (1.5-3.1)	0.00001
ESR > 11 mm/h	50.5	67.1	2.1 (1.5-2.9)	0.00002
Platelets > 292 × 109/L	71.9	46.6	2.2 (1.5-3.1)	0.00001
Cervical spine	30.4	92.9	5.7 (3.7-8.9)	0.0000001
TMJ involvement	11.3	96.4	3.2 (1.7-6.0)	0.00006
Shoulder involvement	18.6	96.7	4.1 (2.3-7.4)	0.0000001
Elbow involvement	36.5	91.6	6.3 (4.1-9.5)	0.000001
MCP involvement	47.1	87.6	6.3 (4.3-9.1)	0.000001
PIP involvement	53.4	84.9	6.7 (4.6-9.5)	0.000001
DIP involvement	18.1	94.0	3.5 (2.1-5.7)	0.0000001
Hip involvement	27.0	83.4	1.7 (1.2-2.5)	0.006
Hip osteoarthritis involvement	43.6	75.5	2.4 (1.2-4.8)	0.014
Hip prosthetics involvement	20.0	94.8	4.7 (1.5-14.2)	0.005
Time before hip osteoarthritis > 3.2 years	95.7	57.1	29.3 (3.3-260.1)	0.0001
Ankle involvement	59.8	63.4	2.6 (1.9-3.6)	0.0000001
Tarsus involvement	9.8	95.8	2.5 (1.3-4.6)	0.003
Treatment with oral GCS	38.2	86.5	4.0 (2.7-5.8)	0.0000001
GCS pulse therapy	33.0	87.5	3.5 (2.4-5.1)	0.0000001
Any GCS treatment	69.6	44.8	3.6 (2.6-5.0)	0.0003
Methotrexate	91.6	16.4	6.7 (3.9-11.5)	0.0003
Biologics	61.3	58.8	2.3 (1.6-3.1)	0.000001
No remission	42.2	66.8	1.5 (1.1-2.0)	0.022
Time before remission > 3.1 years	61.0	53.3	1.8 (1.3-2.5)	0.0006
No flare	86.3	20.1	1.6 (1.01-2.5)	0.046

Data are n (%). BMI: Body mass index; CRP: C-reactive protein; DIP: Distal interphalangeal joints; ESR: Erythrocyte sedimentation rate; GCS: Glucocorticosteroids; JIA: Juvenile idiopathic arthritis; MCP: Metacarpophalangeal joints; PIP: Proximal interphalangeal joints.