Diagnostic significance of complete blood cell count and hemogram-derived markers for neonatal sepsis at Southwest Public Hospitals, Ethiopia

Table 3 Determination of predictive values of some complete blood count values and hemogram-derived markers for neonate sepsis

Hemogram derived markers	Sensitivity	Specificity	PPV	NPV	Cut-off value	AUC	95%CI	P value
WBC	55	89	83.3	66.4	> 11.42	0.81	(0.722-0.848)	< 0.001
NEUTR	67	81	77.9	71.1	> 6.76	0.801	(0.763-0.84)	< 0.001
MONO	67	95	93.1	74.2	> 0.86	0.782	(0.74-0.825)	< 0.001
NLR	57	80	74	65	> 4.29	0.740	(0.695-0.785)	< 0.001
PLR	90	100	100	90	> 903.7	0.69	(0.642-0.737)	< 0.001
MPVPCR	47	92	85.5	63.4	> 0.187	0.718	(0.673-0.764)	0.394
MLR	68	95	93.2	74.8	> 0.26	0.828	(0.791-0.865)	< 0.001
RPR	82	44	59.4	71.0	> 0.051	0.586	(0.534-0.638)	0.001
LMR	84	53	64.1	76.8	< 0.4	0.169	(0.132-0.206)	< 0.001

Data are expressed as percentage, frequency, P < 0.05 is considered as significant. PPV: Positive predictive value; NPV: Negative predictive value; AUC: Area under the curve; 95%Cl: At 95% confidence interval; WBC: White blood cell; NEUTR: Neutrophils; MONO: Monocyte; NLR: Neutrophils to lymphocyte ratio; PLR: Platelet to lymphocyte ratio; MPVPCR: Mean platelet volume to platelet count ratio; MLR: Monocyte to lymphocyte ratio; RPR: Red blood cell width to platelet count ratio; LMR: Lymphocyte to monocyte count ratio.