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©The Author(s) 2023.
World J Clin Pediatr. Dec 9, 2023; 12(5): 350-358
Published online Dec 9, 2023. doi: 10.5409/wjcp.v12.i5.350
Published online Dec 9, 2023. doi: 10.5409/wjcp.v12.i5.350
Table 2 Demographics, treatments, and outcomes of previously reported children with leukemia/lymphoma and type B lactic acidosis
Ref. | Primary diagnosis | Age in yr, Sex | Clinical manifestation | Initial lactate in mmol/L | Blood glucose in mg/dL | Hepatic involvement | Renal involvement | Treatment | Clinical course | |
Lactic acidosis | Outcome | |||||||||
Type B lactic acidosis-Warburg effect | ||||||||||
Field et al[8] | Relapsed ALL | 4, M | Bleeding, hepatosplenomegaly | 20.2 | NR | Yes | NR | Bicarbonate, radiotherapy, chemotherapy | Improved but recurred | Death from disease |
ALL | 8, M | NR | 9.9 | NR | NR | NR | Bicarbonate, chemotherapy | Improved but recurred | Death from infection | |
Coleman et al[9] | Relapsed T-ALL | 2, M | Lymphadenopathy, splenomegaly, dyspnea | 24.6 | 74 | No | NR | Bicarbonate, thiamine, insulin, methylglyoxal | Improved but recurred | Death from disease |
Ali et al[10] | Relapsed B-ALL | 12, M | Poor appetite, weight loss, abdominal pain | 12.0 | NR | No | Yes | Bicarbonate, chemotherapy | Improved but recurred | Death from infection |
Révész et al[11] | Relapsed Burkitt lymphoma | 8, M | Seizure, altered mental status, dyspnea, polydipsia, polyuria | 24.0 | 93 | No | Yes | Bicarbonate, thiamine, chemotherapy, radiotherapy | Improved but recurred | Death from disease |
Sillos et al[3] | Relapsed T-ALL | 11, F | Altered mental status | 10.8 | 47 | Yes | No | Bicarbonate, CRRT, chemotherapy | Improved but recurred | Death from disease |
Relapsed T-ALL | 17, M | Altered mental status, dyspnea, edema | 16.0 | 132 | No | No | Bicarbonate | Worsened | Death from disease | |
T-NHL | 18, F | Fever, weight loss, lymphadenopathy, splenomegaly, dyspnea | 15.4 | 44 | Yes | No | Bicarbonate, chemotherapy | Resolved but recurred | Death from disease | |
Hayek and Srinivasan[12] | B-ALL | 7, M | Anemia, lymphadenopathy, hepatosplenomegaly | 8.4 | 96 | Yes | Yes | Bicarbonate, PD, chemotherapy | Resolved after chemotherapy | CR |
Rastogi et al[13] | Burkitt lymphoma, HIV | 11, M | Fever, hepatosplenomegaly, periorbital and pedal edema | 4.2 | 26 | Yes | NR | Bicarbonate, glucagon | Improved | Death from disease |
Luscri et al[14] | Relapsed B-ALL | 7, M | Fever, ascites, dyspnea | 5.5 | 33 | Yes | NR | Bicarbonate, CRRT | Worsened | Death from LA, disease |
Kulkarni et al[15] | Burkitt lymphoma | 12, M | Dyspnea, hepatomegaly, abdominal pain | 21.0 | Normal | Yes | Yes | Bicarbonate, chemotherapy | Resolved after chemotherapy | CR |
Terpe et al[16] | B-ALL | 11, M | Nausea, dyspnea, lymphadenopathy, abdominal pain, pancytopenia | 21.0 | 48 | Yes | Yes | Bicarbonate, chemotherapy | Worsened | Death from LA, ACS |
Gökçe et al[17] | B-ALL | 13, M | Weight loss, nausea, bone pain | 62.0 | 97 | Yes | Yes | Bicarbonate, chemotherapy | Resolved after chemotherapy | CR |
Schuh et al[18] | Relapsed B-ALL | 12, M | Fever, abdominal pain, bicytopenia | 14.8 | 80 | Yes | Yes | Chemotherapy | Worsened | Death from disease |
Narayani et al[19] | ALL | 2, M | Fever, pancytopenia | 13.5 | 96 | NR | No | Bicarbonate, chemotherapy | Resolved after chemotherapy | CR |
Khera et al[20] | T-ALL | 11, F | Poor appetite, weight loss, nausea, dyspnea, bicytopenia | 20.0 | 104 | No | No | Bicarbonate, chemotherapy | Resolved after chemotherapy | CR |
O'Rourke et al[21] | Burkitt leukemia | 13, M | NR | NR | Low | NR | NR | Chemotherapy | Worsened | Death from LA |
Hui et al[22] | Relapsed B-ALL | 17, F | Poor appetite, weight loss, bicytopenia | 15.0 | NR | NR | No | Bicarbonate CRRT | Improved | NR |
This study | Burkitt leukemia | 10, M | Poor appetite, nausea, vomiting | 3.7 | 49 | No | Yes | Rituximab, chemotherapy | Resolved after chemotherapy | CR |
Type B lactic acidosis-thiamine deficiency | ||||||||||
Oriot et al[23] | Relapsed ALL, on TPN without vitamin | 3, M | Altered mental status, fever, dyspnea, hepatomegaly | 30.0 | 43 | Yes | No | Bicarbonate, PD, thiamine | Resolved | CR |
Svahn et al[24] | B-ALL, on TPN without vitamin | 0.9, F | Altered mental status | 18.6 | NR | NR | NR | Bicarbonate, multivitamin including thiamine | Resolved | CR |
Didisheim et al[25] | ALL, post-sepsis | 13, M | Fever, abdominal pain, hypotension | 19.6 | NR | NR | NR | ECMO, thiamine | Resolved | CR |
Type B lactic acidosis-medication (s) | ||||||||||
Smolka et al[26] | Relapsed B-ALL, pneumonia (antibiotics including linezolid) | 9, F | Altered mental status, dyspnea | 19.0 | NR | Yes | NR | Bicarbonate, withdraw linezolid | Improved | CR |
- Citation: Permtawee K, Tengsujaritkul M, Choed-Amphai C, Chanthong S, Mankhemthong K, Sathitsamitphong L, Natesirinilkul R, Charoenkwan P. Warburg effect mimicking inborn errors of metabolism in childhood hematologic malignancies: A case-based systematic review. World J Clin Pediatr 2023; 12(5): 350-358
- URL: https://www.wjgnet.com/2219-2808/full/v12/i5/350.htm
- DOI: https://dx.doi.org/10.5409/wjcp.v12.i5.350