Systematic Reviews
Copyright ©The Author(s) 2023.
World J Clin Pediatr. Dec 9, 2023; 12(5): 350-358
Published online Dec 9, 2023. doi: 10.5409/wjcp.v12.i5.350
Table 2 Demographics, treatments, and outcomes of previously reported children with leukemia/lymphoma and type B lactic acidosis
Ref.
Primary diagnosis
Age in yr, Sex
Clinical manifestation
Initial lactate in mmol/L
Blood glucose in mg/dL
Hepatic involvement
Renal involvement
Treatment
Clinical course
Lactic acidosis
Outcome
Type B lactic acidosis-Warburg effect
Field et al[8]Relapsed ALL4, MBleeding, hepatosplenomegaly20.2NRYesNRBicarbonate, radiotherapy, chemotherapyImproved but recurredDeath from disease
ALL8, MNR9.9NRNRNRBicarbonate, chemotherapyImproved but recurredDeath from infection
Coleman et al[9]Relapsed T-ALL2, MLymphadenopathy, splenomegaly, dyspnea24.674NoNRBicarbonate, thiamine, insulin, methylglyoxalImproved but recurredDeath from disease
Ali et al[10]Relapsed B-ALL12, MPoor appetite, weight loss, abdominal pain12.0NRNoYesBicarbonate, chemotherapyImproved but recurredDeath from infection
Révész et al[11]Relapsed Burkitt lymphoma8, MSeizure, altered mental status, dyspnea, polydipsia, polyuria24.093NoYesBicarbonate, thiamine, chemotherapy, radiotherapyImproved but recurredDeath from disease
Sillos et al[3]Relapsed T-ALL11, FAltered mental status10.847YesNoBicarbonate, CRRT, chemotherapyImproved but recurredDeath from disease
Relapsed T-ALL17, MAltered mental status, dyspnea, edema16.0132NoNoBicarbonateWorsenedDeath from disease
T-NHL18, FFever, weight loss, lymphadenopathy, splenomegaly, dyspnea15.444YesNoBicarbonate, chemotherapyResolved but recurredDeath from disease
Hayek and Srinivasan[12]B-ALL7, MAnemia, lymphadenopathy, hepatosplenomegaly8.496YesYesBicarbonate, PD, chemotherapyResolved after chemotherapyCR
Rastogi et al[13]Burkitt lymphoma, HIV11, MFever, hepatosplenomegaly, periorbital and pedal edema4.226YesNRBicarbonate, glucagonImprovedDeath from disease
Luscri et al[14]Relapsed B-ALL7, MFever, ascites, dyspnea5.533YesNRBicarbonate, CRRTWorsenedDeath from LA, disease
Kulkarni et al[15]Burkitt lymphoma12, MDyspnea, hepatomegaly, abdominal pain21.0NormalYesYesBicarbonate, chemotherapyResolved after chemotherapyCR
Terpe et al[16]B-ALL11, MNausea, dyspnea, lymphadenopathy, abdominal pain, pancytopenia21.048YesYesBicarbonate, chemotherapyWorsenedDeath from LA, ACS
Gökçe et al[17]B-ALL13, MWeight loss, nausea, bone pain62.097YesYesBicarbonate, chemotherapyResolved after chemotherapyCR
Schuh et al[18]Relapsed B-ALL12, MFever, abdominal pain, bicytopenia14.880YesYesChemotherapyWorsenedDeath from disease
Narayani et al[19]ALL2, MFever, pancytopenia13.596NRNoBicarbonate, chemotherapyResolved after chemotherapyCR
Khera et al[20]T-ALL11, FPoor appetite, weight loss, nausea, dyspnea, bicytopenia20.0104NoNoBicarbonate, chemotherapyResolved after chemotherapyCR
O'Rourke et al[21]Burkitt leukemia13, MNRNRLowNRNRChemotherapyWorsenedDeath from LA
Hui et al[22]Relapsed B-ALL17, FPoor appetite, weight loss, bicytopenia15.0NRNRNoBicarbonate CRRTImprovedNR
This studyBurkitt leukemia10, MPoor appetite, nausea, vomiting3.749NoYesRituximab, chemotherapyResolved after chemotherapyCR
Type B lactic acidosis-thiamine deficiency
Oriot et al[23]Relapsed ALL, on TPN without vitamin3, MAltered mental status, fever, dyspnea, hepatomegaly30.043YesNoBicarbonate, PD, thiamineResolvedCR
Svahn et al[24]B-ALL, on TPN without vitamin0.9, FAltered mental status18.6NRNRNRBicarbonate, multivitamin including thiamineResolvedCR
Didisheim et al[25]ALL, post-sepsis13, MFever, abdominal pain, hypotension19.6NRNRNRECMO, thiamineResolvedCR
Type B lactic acidosis-medication (s)
Smolka et al[26]Relapsed B-ALL, pneumonia (antibiotics including linezolid)9, FAltered mental status, dyspnea19.0NRYesNRBicarbonate, withdraw linezolidImprovedCR