Brain metabolic profile assessed by magnetic resonance spectroscopy in ‎‎children with Down syndrome: Relation to intelligence quotient

doi:10.5409/wjcp.v12.i5.310

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World Journal of Clinical Pediatrics

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2219-2808

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Clin Pediatr. Dec 9, 2023; 12(5): 310-318
Published online Dec 9, 2023. doi: 10.5409/wjcp.v12.i5.310

Table 4 Multivariate analysis of the brain metabolite ratios that significantly affect intelligence quotient in children with down syndrome

	Unstandardized coefficients		Standardized coefficients	t value	P value
	B	SE	Beta	t value	P value
F NAA/Cr	10.123	2.260	0.726	4.480	< 0.001¹
T Cho/Cr	10.950	3.347	0.541	3.272	0.002¹
O Cho/Cr	5.695	3.391	0.324	1.679	0.102

¹P < 0.01 is significant.

Dependent variable: IQ; Cho: Choline; Cr: Creatine; F: Frontal; IQ: Intelligence quotient; NAA: N-acetyl aspartate; O: Occipital; T: Temporal.

Citation: El Feil NS, Elmahdy HS, Elmahdy RA, Aboelezz‎ AAE, Dawoud HS, Al-Beltagi M. Brain metabolic profile assessed by magnetic resonance spectroscopy in ‎‎children with Down syndrome: Relation to intelligence quotient. World J Clin Pediatr 2023; 12(5): 310-318
URL: https://www.wjgnet.com/2219-2808/full/v12/i5/310.htm
DOI: https://dx.doi.org/10.5409/wjcp.v12.i5.310